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Conforma HA

View Clinical Data and Publications

Conforma
HA

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CONFORMA HA
Increases in-Vitro
Collagen Production

In an in-vitro study utilizing normal human dermal fibroblasts (NHDF)
 

Test Samples were prepared at identical concentrations

  • Test product – Conforma-HA (0.5% HA, 99.5% water)

  • Comparator  –  (0.5% sodium hyaluronate, 99.5% water)
     

Experimental Methods

  • Test and comparator products diluted in cell media and added to the cells at the following final concentrations: 0.003, 0.006, 0.012%

  • Cellular synthesis of Procollagen type I C-peptide (PIP) in NHDF cells evaluated via ELISA.

  • Ascorbic acid (0.001%) used as a positive control

  • Blank control represents no product administered

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Conforma-HA significantly increased the intracellular collagen synthesis by 118-158% relative to the comparator in a concentration-dependent manner

CONFORMA HA
Improves Skin Elasticity

In a Study of 22 adult females, aged 29-59 years, subjects were assigned to utilize conformationally changed-HA 0.5% HA (half the concentration of Conforma-HA)  formulated with 2% 1,2-hexanediol, applied twice daily

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Measurement of Skin Elasticity

  • Skin elasticity was measured 3 times on both cheeks of the subject using Cutometer® MPA580 (Enviroderm, UK).

  • After negative pressure was applied to the skin, the ability of the skin to return to its previous position, i.e., elasticity, is calculated as the R2 value.

  • Skin elasticity improves as the R2 value increases.

##:p<0.025(=5%/2) by Friedman test, post hoc Wilcoxon signed rank test with with Bonferroni correction F: p<0.05 by repeated measures ANOVA

Conforma HA
Reduces Eye Wrinkles

In a Study of 22 adult females, aged 29-59 years, subjects were assigned to utilize conformationally changed-HA 0.5% HA (half the concentration of Conforma-HA) formulated with 2% 1,2-hexanediol, applied twice daily

Measurement of eye wrinkles

  • The same area around the eyes is pictured using PRIMOS CR® (LMI Technologies, Canada) Small Field technology.

  • The average roughness of the wrinkles around the eyes (Crow's feet) is expressed as a Ra (µm) value. 

  • As the Ra value decreases, it means that the wrinkles around the eyes are improved.

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**:p<0.05 by repeated measures ANOVA, post hoc Boferroni correction
##:p<0.025(=5%/2) by Friedman test, post hoc Wilcoxon signed rank test with with Bonferroni correction
F: p<0.05 by repeated measures ANOVA

ConformaHA
Demonstrates
‘Push-Pull’ Activity

​In a study to compare the transdermal permeability of Conforma HA-mixed with Lidocaine (9.6%) and 9.6% lidocaine cream (5-MC® cream, U Pharmaceuticals, Korea) to full thickness murine abdominal skin.

  • Equal volumes of Conforma-HA-Lidocaine and 5-MC cream were applied over an area of 0.64 cm2 for 5 minutes.
     

  • Skin absorption was assayed via LC/MS/MS for lidocaine.
     

  • Results:  Conforma-HA Delivers 4.3 times more lidocaine in the first 5 minutes

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This ability to facilitate movement other molecules across the skin allows the user to apply Conforma-HA with other agents to improve skin penetration

Conforma HA 

CLINICAL STUDY: J Cosmet Dermatol 2022;00:1–9

Novel conformation of hyaluronic acid
with improved cosmetic efficacy


See the clinical study results for Conform HA in the following areas: 
 

  • Skin hydration

  • Transepidermal water loss

  • Skin elasticity 

  • Wrinkles (Crows feet) 

  • Facial Sagging

  • Skin density 

  • Collagen synthesis 

Conforma HA 

GENERAL HYALURONIC ACID 

Factoids about Hyaluronic Acid 

Read more about he benefits of Hyaluronic Acid in the human body 

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